COVID-19 The epidemic continues to find more infected people, especially in the Eastern Economic Corridor (EEC) area, which is the highest controlled area. There became a public health crisis which doctors, nurses and emergency room are the front line at the risk of being exposed to germs easily. It increased workflows and processes resulting in long working hours. The fatigue and mental stress became stressful. It affects the body and mind both in the short and long term. The purpose of this research was to study the factors affecting the quality of life of emergency room physicians and nurses in public and private hospitals affected by COVID-19 in the EEC area. It is a specific population. The study was conducted from a population of 400 people. The targets were divided into 2 groups: 1) emergency room physicians 2) emergency room nurses. There perform both full-time and temporary contract work in emergency rooms during COVID-19 in public and private hospitals in the EEC area. The analyze data conducting both qualitative and quantitative research. It is a tool to perceive an opinion piece on current situation factors (WRQoL) that affect the quality of work life to measure quality of work life. A total of 472 real data were collected using both descriptive and reference statistics. The study found that the factors affecting the quality of life of doctors and emergency room nurses in public and private hospitals affected by COVID-19 in the EEC area with the highest mean were social relativity factors, including the team that support patients are part of the success. The psychological factors include that I have pride in myself every time and I take care of and keep patients out of danger. The physical factors include work performed with too much risk of harm to health and environmental factors such as receiving compensation for risks during COVID-19 delayed and overwhelmed. The results of the analysis of the importance of factors affecting the quality of life from the hypothesis. It found that there were no significant differences between public and private hospitals in the overall quality of life of physicians and emergency room nurses at the .05 level. There are improving the quality of life passed the assessment criteria were consistent with the empirical data. The probability chi-squared was .170, the relative chi-squared was 1.189, the concordance index was .979, and the mean squared root index of the error estimation was .020. The recommendations were as a result of this research, hospital administrators and agencies that utilize the research can apply factors affecting the quality of life of physicians and nurses to improve quality of life in order to create models and contextual guidelines which on each organization in accordance with the policy and culture. It can also be adapted to other agencies that need to receive critically ill patients and should be studied further developing a model to enhance the quality of life of personnel working in emergency room departments under the COVID-19 outbreak.