Abstract
This research is continuous innovation and an effective additional protocol to reduce and control the COVID-19 pandemic by creating free COVID-19-surfaces and environments without the required routine cleaning process. A prototype of a clear “DSci sticker” has been coated with a solution of Ag-TiO2/WPU nanocomposite, which is a smart material that can generate active species with long-lasting property. Our sticker with virucidal efficacy of 99.99% against SARS-CoV-2 according to ISO 21702: 2019 standard has been developed. The ROS and Ag+ accumulate on the surface of virus particles and denature the viral proteins, offering broad action against unspecified targets (all virus proteins, not just the spike proteins), which could be helpful in all SARS-CoV-2 variants of concern. In addition, the cytotoxicity test was determined according to ISO 10993-5: 2009 standard to ensure that our sticker is safe and non-toxic to humans and animals (% cell viability >70%). To take this research into real practice, we tested antiviral efficiency against SARS-CoV-2 under the simulated practical conditions following ISO 21702: 2019. We mimicked a spreading of virus in air (coughing and sneezing) using a direct spraying model. The results showed that our sticker completely eradicated SARS-CoV-2. Our sticker is used for medical equipment with clear readability and labelling. It reduces risks of high-touch contaminated surfaces and its virucidal efficacy lasts for at least three months (≥99.90%). The prototype is prompted for Thai FDA registration of class 1 medical devices. Furthermore, a production process in this work can be scaled up for an industrial production.
