The 5th Health District's coronavirus (COVID-19) study aims to study the impact on mental health and factors affecting the mental health of people in the 5th health district from the covid-19 pandemic. Qualitative research studies from 4 groups of informants: patient groups, relatives of patients, Medical profession and Non-Communicable diseases patients The 5th health district is Kanchanaburi, Suphan Buri, Nakhon Pathom, Ratchaburi, Samut Sakhon, Samut Songkhram, Phetchaburi and Prachuap Khiri Khan. The results of the study were as follows: 1. Impact on mental health on covid-19 pandemic Coronavirus 2019 patients and relatives was found in the cognitive to be shocked, scared and believed that when infected with coronavirus, it would die. The patient's relatives do not blame the patient, but they are encouraged and want the patient to go with the flow of life. In the emotion part, both patient and relatives are worry about their physical and mental state as they feel undervalued, disgusted and stigmatized by family members and surrounding society, which patients choose to switch off their communication channel to avoid the shame that could be received. Moreover, in the part of behavior: patients and relatives adapt their daily life with exercise to keep themselves healthy. In the part of relationship, the result showed a decrease in family interaction. There has been an increase in the risk of developing psychiatric disorders. Patients are at risk of depression, relatives have insomnia and need to take medication, and feel like dying. A Non-Communicable diseases patient found that in the cognitive part, they believe that once infected, they are more likely to die. Having a congenital disease is easier to get infected. When they are going out, they will get infected and will be disgusted by the surrounding society. In the emotional part, they were depressed when they see COVID-19 patients detained as people who have no kith and kin. They felt angry and blamed those who bring the infection into the village, and being stigmatized by others. In the part of behaviors, the reforming of daily life has been adjusted by wearing a face mask, eating healthy food and washing their hand regularly. In the part of relationship, there was a decrease in meeting in person. It is not possible to come to visit normally. However, for healthcare worker, they are still in the relationship. This group of patients are well adapted and stay strong. Nevertheless, there were some patients who already got mental health. Therefore, being stressed and thought of suicide were obtained by those patients. For medical profession, in the part of cognitive, they are concerned because this virus is a new incidence that has spread rapidly and terribly. They need to be more careful when taking care of patients and take care of themselves. The working patterns has been changed, such as wearing hot protective equipment. By working harder than normal and having limited human resources during the pandemic, they emotionally feel exhausted, fear, anxiety, stress, paranoia and alienation from society, being shown to behave disgusted, stigmatized both to themselves and their families. In the part of behavior, their behavior has been changed to ensure safety and prevent themselves to get infected. In the part of relationship, the study found that they need to live separately with their families. For example, they could not return to their home. However, they still got help and understanding from their families. From this study, there is no sign of metal health in this group of people. 2. Factors affecting mental health changes in the situation of the spreading of COVID-19 1. Assistive factors among people infected with coronavirus 2019 were found to be expressed with disgust with the assistance, lack of intimateness and inappropriate communication. Patients are requiring assistance, such as the practice when they are quarantine and when they are back to normal lifestyles also treatment guidelines and effective communication channels with patient’s families and relative in groups. In the group of relative, the patient receives help of their colleague neighbors, public health volunteers, local administrations. They are encouraging each other so they got cheer up among themselves. Among patients with chronic non-communicable diseases, they received the help from King Vajiralongkorn, creating the delight from people. The government has a policy of grants. Compensation for the people who are not able to work. There's a health authority, volunteers are assisting in various areas of healthcare workers, supported by family members, government. An organization has donated protective items during the duty. 2. Social environmental factors among people infected with coronavirus 2019, there was a lack of understanding of the disease and treatment guidelines. Therefore, people are anxious and afraid of getting the disease, and received information online that create the lack of understanding about the diseases. In a group of relatives, they get a disgusting stance from neighbors. Social media is a funnel of misinformation. Among patients with chronic non-communicable diseases. It found that communities in society are also generous to each other, especially volunteer in the village. They provide help to the public, provides useful advices of how to use face masks, washes hands, gives out masks and alcohol. Hence, it makes people feel that they are not abandoned. In the medical profession group, there are families and associates who are supportive. There's a media network, headman, but there are still people who do not understand to act disgusted. 3. Occupational/economic factors, all 4 groups are affected in income. There was a decrease in income among people infected with coronavirus 2019 and relatives were left out of work, closing down the business and there is no income. 4. Access factors to the health service system, receiving the medicine by mail has been introduced and at the general practice for the non-communicable diseases patient and providing the staffs from NHS to take care the patient closely with continuous receiving of medicine and more convenience. 5. Educational factors are indirect factors caused children to study online, causing patients with non-communicable diseases to take care of themselves, thus increasing difficulties to everyone. 6. Legal and Order The government or institute are concerned and value the work of healthcare workers by providing COVID-19 insurance to healthcare workers.